EFFECT OF COSMOS CAUDATUS KUNTH LEAVES ON THE LIPID PROFILE OF A HYPERLIPIDEMIA-INDUCED ANIMAL MODEL

Vikneswari Perumal, Azizah A. Hamid, Amin Ismail, Khozirah Saari, Faridah Abas, Intan S. Ismail, Maulidiani ., Nordin H. Lajis, Alfi Khatib

Abstract


Hyperlipidemia, a metabolic disorder closely associated with the modern life-style and eating habits, is increasingly prevalent among the world population. This study was conducted on obese rats to evaluate the efficacy of Cosmos caudatus leaves as a treatment of hyperlipidemia. Hyperlipidemic conditions were induced in rats by submitting them to a high-fat diet during 3 months. After this, the rats were administered 200 mg/kg body weight of an ethanolic C. caudatus leaf extract or 35 mg/kg body weight atorvastatin for four weeks. The rats treated with the C. caudatus extract showed a significant (P<0.05) reduction of plasma triglycerides, total cholesterol, low density lipoprotein-cholesterol and glucose, and a significant (P< 0.05) increase in high density lipoprotein-cholesterol and Atherogenic Index values. The study indicated that supplementation with C. caudatus has a potential for the treatment of hyperlipidemia.


Keywords


Hyperlipidemia; High Fat Diet; Cosmos caudatus; Atorvastatin; Rats; Obesity

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References


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Copyright (c) 2014 Vikneswari Perumal, Azizah A. Hamid, Amin Ismail, Khozirah Saari, Faridah Abas, Intan S. Ismail, Maulidiani ., Nordin H. Lajis, Alfi Khatib

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Journal of Food Chemistry and Nutrition
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