The Effect of Morus alba, Alloe barbadensis Miller, Allium sativum, Annona squamosal, and other Medicinal Plants as A Therapeutic Agent for Diabetes Mellitus

Mehwish Shabir Hussain, Ammara Munir

Abstract


This review article discusses the prevalence of diabetes. However, due to the limitations of the traditional medications of diabetes, there is growing interest in using medicinal plants that contain specific chemicals such as alkaloids, terpenoids, carotenoids, flavonoids, and glycosides to combat diabetes. Diabetes mellitus is a chronic metabolic disease that affects millions of people worldwide. The extracts of Morus alba, a plant with a long history of traditional use in various cultures, have been shown to possess anti-diabetic properties. This review article summarizes the current research on the use of M. alba and various other medicinal plants extracts including Alloe barbadensis miller, Allium sativum, Annona squamosal, Azadirachta indica, Averrhova bilimbi as a therapeutic agent for diabetes mellitus. Overall, this review paper provides a comprehensive analysis of the potential of various medicinal plants extracts as a cure for diabetes mellitus and highlights the need for further research to fully evaluate their therapeutic potential.

Keywords


Diabetes mellitus; Medicinal plants; Morus alba; Mulberry; Alkaloids; Flavonoids; Carotenoids; Terpenoids; Glycosides

Full Text:

PDF

References


Afrisham, R., M. Aberomand, M. A. Ghaffari, A. Siahpoosh and M. Jamalan. 2015. Inhibitory Effect of Heracleum persicum and Ziziphus jujube on activity of Alpha-Amylase. Journal of Botany, 1-8. Doi: 10.1155/2015/824683.

Andallu, B., A.V.V. Kumar and N.C. 2012. Oxidative stress in streptozocin-diabetic rats: Amelioration by mulberry (Morus indica L.) leaves. Chin. J. Integr. Med. 1–6.

Bondada, A., V.K. Allagadda Venkata and V. Nallanchakravarthula. 2014. Influence of mulberry (Morus indica L.) leaves on antioxidants and antioxidant enzymes in STZ-diabetic rats. International Journal of Diabetes in Developing Countries, 34: 69–76.

Butt, M.S., A. Nazir, M.T. Sultan and K. Schroën. 2008. Morus alba L. nature’s functional tonic. Trends Food Science. Technolog, 19: 505–512.

Chang, L.W., L.J. Juang, B.S. Wang, M.Y. Wang, H.M. Tai, W.J. Hung, Y.J. Chen and M.H. Huang. 2011. Antioxidant and antityrosinase activity of mulberry (Morus alba L.) twigs and root bark. Food Chem. Toxicol. 49: 785–790.

Chen, F., N. Nakashima, I. Kimura, M. Kimura, N. Asano and S. Koya. 1995. Potentiating effects on pilocarpine-induced saliva secretion, by extracts and N-containing sugars derived from mulberry leaves, in streptozocin-diabetic mice. Biological and Pharmaceutical Bulletin, 18: 1676–1680.

Cui, L., M. Na, H. Oh, E.Y. Bae, D.G. Jeong, S.E. Ryu, S. Kim, B.Y. Kim, W.K. Oh and J.S. Ahn. 2006. Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorganic and Medicinal Chemistry Letters, 16: 1426–1429.

Davis SN, 2006. Insulin, Oral Hypglycemic Agents, and the Pharmacology of Endocrine Pancreas. Goodman and Gilman’s the Pharmacologucal Basis of Therapeutics. NY Giese: Pergamon Press, p. 1487-518. null.

Dey, L., A. S. Attele and C. S. Yuan. 2002. Alternative therapies for type 2 diabetes. Alternative Medicine Revview. PMID, 7: 45-58. 11896745.

Dheer, R. and P. Bhatnagar. 2010. A study of the antidiabetic activity of Barleria prionitisLinn. Indian Journal of Pharmacology, 42(2): 70. doi: 10.4103/0253-7613.64493, PMID: 20711368, PMCID: PMC2907017.

Diabetes. International Diabetes Federation, idf.org/aboutdiabetes/what-is-diabetes.html.

Eidi, A., M. Eidi and E. Esmaeili. 2006. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocininduced diabetic rats. Phytomedicine. PMID, 13(9): 624-9. doi: 10.1016/j.phymed.2005.09.010, 17085291.

Geetha, M. and A. Wahi. 2001. Antidiabetic activity of Barleria prionitis Linn. Journal of Natural Remedies. 1(1): 64-6.

Hansawasdi, C. and J. Kawabata. 2006. α-Glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia, 77: 568–573.

Hashmat I, Azad H, Ahmed A. 2012. Neem (Azadirachta indica A. Juss)-A nature’s drugstore: an overview. Int Res J Biol Sci. 1: 76-9

Helin, Wei., L. Siyuan, L. Yijun, Ma. Chuanhui, W. Dongying, T. Jiayun and F. Jiafu. 2018. A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus. The American Journal of Chinese Medicine, 46 (08): 1743-1770.

Kaleem M, Asif M, Ahmed Q, Bano B. 2006. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J, 47(8): 670-5. PMID: 16865205.

Katsube, T., M. Yamasaki, K. Shiwaku, T. Ishijima, I. Matsumoto, K. Abe and Y. Yamasaki. 2010. Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice. J. Sci. Food Agric. 90: 2386–2392.

Kazi, S. 2014. Use of traditional plants in diabetes mellitus. International Journal of Pharmaceutics, 4(4): 283-9.

Khosla P, Bhanwra S, Singh J, Seth S, Srivastava R. 2000. A study of hypoglycaemic effects of Azadirachta indica (Neem) in normal and alloxan diabetic rabbits. Indian J Physiol Pharmacol. 44(1): 69-74. PMID: 10919098.

Kimura, M., F. Chen, N. Nakashima, I. Kimura, N. Asano and S. Koya. 1995. Antihyperglycemic effects of N-containing sugars derived from mulberry leaves in streptozocin-induced diabetic mice. J. Tradit. Med. 12: 214–219.

Kumar S, Alagawadi K. 2010. Hypoglycemic effect of Argyreia nervosa root extract in normal and streptozotocin-diabetic rats. Der Pharmacia Lettre. 2(2): 333-7.

Kumar, A., K. Gnananath, S. Gande, E. Goud, P. Rajesh and S. Nagarjuna. 2011. Anti-diabetic Activity of Ethanolic Extract of Achyranthes aspera Leaves in Streptozotocin induced diabetic rats. Journal of Pharmacy Research. 4: 3124-5.

Liu, H.Y., M. Fang and Y.Q. Zhang. 2014. In vivo hypoglycaemic effect and inhibitory mechanism of the branch bark extract of the mulberry on STZ-induced diabetic mice. Science World , 1–11.

Lv, Q., W. Xia, W.Q. Zhang and G.A. Luo. 2007. Purification and analyses of polysaccharides in mulberry leaves. Food and Fermentation Industries 33: 167–170.

Mukesh, R. and Namita. 2013. Medicinal Plants with Antidiabetic Potential-A Review. American-Eurasian Journal of Agricultural and Environmental Science, 13(1): 81-94.

Pawar, A. and N. Vyawahare. 2014. Phytocemical and pharmacological profile of Biophytum Sensitivum L DC. International Journal of Pharmacy and Pharmaceutical Science,. 6(11): 18-22.

Puri, D. 2001. The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. Journal of ethnopharmacology, 78(1): 89-93. doi: 10.1016/S0378- 8741(01)00306-3.

Pushparaj P, Tan C, Tan B. 2000. Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats. Journal of Ethnopharmacology. 72(1): 69-76. doi: 10.1016/S0378- 8741(00)00200-2/

Shinde, V., A. Borkar and R. Badwaik. 2014. Evaluation and comparative study of hypoglycemic activity of aloe Barbadensis Miller with oral hypoglycemic drugs (glibenclamide and metformin) in rats. International Journal of Medical and Pharmaceutical Sciences. 4(6): 31-6.

Singh, R., P. Rajasree and C. Sankar. 2012. Screening for anti-diabetic activity of the ethanolic extract of Bryonia Alba roots. International Journal of Pharmaceutical and Bioogical Science, 2(3): 210-5.

Sugiyama, M., T. Katsube, A. Koyama and H. Itamura. 2013. Varietal differences in the flavonol content of mulberry (Morus spp.) leaves and genetic analysis of quercetin 3-(6-malonylglucoside) for component breeding. Journal of Agricultural and Food Chemistry, 61: 9140–9147.

Tao, Y., Y. Zhang, Y. Cheng and Y. Wang. 2013. Rapid screening and identification of α-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR. Biomed. Chromatogr. 27: 148–155.

Venkatesh, R.K. and S. Chauhan. 2013. Mulberry: Life enhancer. 2: 271–278, 2008. Wang, Y., L. Xiang, C. Wang, C. Tang and X. He. Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract. Journal of Medicinal. Plant Research. PLoS One 8: 1–10.

Yang, X., L. Yang and H. Zheng. 2010. Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats. Food and Chemical Toxicology, 48: 2374–2379.

Zhang, X-F. and B. Tan. 2000. Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmacologica Sinica. PMID, 21(12): 1157-64. 11603293.




DOI: https://doi.org/10.33687/planthealth.01.01.4536

Refbacks



Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.