Linking pesticide exposure with covid-19 among agricultural professionals in perspectives of immunity and safety: A review

Wali Muhammad, Ijaz Ahmad, Hassan Tariq Bhatti, Muhammad Zubair

Abstract


Pesticides are commonly used in our agro-ecosystems for controlling the insect pests, diseases and weeds. They are harmful for the people’s immune system. There is an important role of pesticides in our food chain and health systems. Unsafe use of pesticides in pandemic situation caused by COVID-19 may lead to reduction of immunity level in individuals exposed to sub lethal doses of pesticides. Arial sprays of pesticides are reported to be carcinogenic especially for those workers who are directly exposed to pesticides. Strengthened immune system is the first wall of safety against COVID-19. Peoples must consider the safe use of pesticides when they are thinking to strength their immune system. Off drifts of pesticides are suggested to be avoided for a better chance to survive in pandemic.


Keywords


COVID-19; Immune system; Pesticide use; Agriculture frontline workers

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References


Aguilar-Garduño, C., Lacasaña, M., Blanco-Muñoz, J., Rodríguez-Barranco, M., Hernández, A.F., Bassol, S., González-Alzaga, B., Cebrián, M.E., 2013. Changes in male hormone profile after occupational organophosphate exposure. A longitudinal study. Toxicology 307, 55-65.

Ahmad, M., Muhammad, W., Sajjad, A., 2020. Ecological Management of Cotton Insect Pests, Cotton Production and Uses. Springer, pp. 213-238.

Aktar, W., Sengupta, D., Chowdhury, A., 2009. Impact of pesticides use in agriculture: their benefits and hazards. Interdisciplinary Toxicology 2, 1-12.

Barnett, J.B., Rodgers, K.E., 1994. Pesticides, Immunotoxicology and Immunopharmacology. New York, Raven Press.

Caldas, E.D., Conceiçao, M.H., Miranda, M.C.C., de Souza, L.C.K.R., Lima, J.F., 2001. Determination of dithiocarbamate fungicide residues in food by a spectrophotometric method using a vertical disulfide reaction system. Journal of Agricultural and Food Chemistry 49, 4521-4525.

Chen, J., Saleem, M., Wang, C., Liang, W., Zhang, Q., 2018. Individual and combined effects of herbicide tribenuron-methyl and fungicide tebuconazole on soil earthworm Eisenia fetida. Scientific Reports 8, 1-9.

Colosio, C., Tomasini, M., Cairoli, S., Foa, V., Minoia, C., Marinovich, M., Galli, C.L., 1991. Occupational triphenyltin acetate poisoning: a case report. Occupational and Environmental Medicine 48, 136-139.

Corsini, E., Sokooti, M., Galli, C.L., Moretto, A., Colosio, C., 2013. Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence. Toxicology 307, 123-135.

Dallaire, F., Dewailly, E., Muckle, G., Vézina, C., Jacobson, S.W., Jacobson, J.L., Ayotte, P., 2004. Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik. Environmental Health Perspectives 112, 1359-1364.

Dewailly, E., Ayotte, P., Bruneau, S., Gingras, S., Belles-Isles, M., Roy, R., 2000. Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. Environmental Health Perspectives 108, 205-211.

Dietert, R.R., 2011. Role of developmental immunotoxicity and immune dysfunction in chronic disease and cancer. Reproductive Toxicology 31, 319-326.

Galloway, T., Handy, R., 2003. Immunotoxicity of organophosphorous pesticides. Ecotoxicology 12, 345-363.

Gangemi, S., Gofita, E., Costa, C., Teodoro, M., Briguglio, G., Nikitovic, D., Tzanakakis, G., Tsatsakis, A.M., Wilks, M.F., Spandidos, D.A., 2016. Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases. International Journal of Molecular Medicine 38, 1012-1020.

Hermanowicz, A., Kossman, S., 1984. Neutrophil function and infectious disease in workers occupationally exposed to phosphoorganic pesticides: role of mononuclear-derived chemotactic factor for neutrophils. Clinical Immunology and Immunopathology 33, 13-22.

Hooghe, R.J., Devos, S., Hooghe-Peters, E.L., 2000. Effects of selected herbicides on cytokine production in vitro. Life Sciences 66, 2519-2525.

Kacmar, P., Pistl, J., Mikula, I., 1999. Immunotoxicology and veterinary medicine. Acta Veterinaria Brunensis 68, 57-79.

Kumar, R., Singhal, L.K., Singh, B.P., Chauhan, R.S., 2002. Effect of butachlor on cell-mediated immunity in chicken. Journal of Immunology and Immunopathology 4, 84-87.

Lee, G., Choi, K., 2020. Adverse effects of pesticides on the functions of immune system. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, DOI: 10.1016/j.cbpc.2020.108789.

Li, Q., 2007. New mechanism of organophosphorus pesticide-induced immunotoxicity. Journal of Nippon Medical School 74, 92-105.

Luebke, B., 2002. Pesticide-induced immunotoxicity: are humans at risk? Human and Ecological Risk Assessment: An International Journal 8, 293-303.

Mokarizadeh, A., Faryabi, M.R., Rezvanfar, M.A., Abdollahi, M., 2015. A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences. Toxicology Mechanisms and Methods 25, 258-278.

Mondal, S., Ghosh, R.C., Mate, M.S., Karmakar, D.B., 2009. Effects of acetamiprid on immune system in female Wistar rats, Proceedings of the Zoological Society. Springer, pp. 109-117.

Mora, G.C., Schickler, E., 2020. Broad Support for Farmworker Protections in COVID-19 Context.

Muhammad, W., Ahmad, I., Bhatti, H.T., Irshad, M., Akhtar, U., 2019. Effect of different fungicide seed treatments on the occurrence of gram wilt. Plant Protection 3, 91-96.

Nalwanga, E., Ssempebwa, J.C., 2011. Knowledge and practices of in-home pesticide use: a community survey in Uganda. Journal of Environmental and Public Health Volume 2011, Article ID 230894, 7 pages. doi:10.1155/2011/230894.

Potti, A., Sehgal, I., 2005. Exposure to pesticides increases levels of uPA and uPAR in pre-malignant human prostate cells. Environmental Toxicology and Pharmacology 19, 215-219.

Prater, M.R., 2002. Immunotoxicity of dermal permethrin and cis-urocanic acid: effects of chemical mixtures in environmental health. Virginia Tech.

Queiroz, M.L.S., Bincoletto, C., Perlingeiro, R.C.R., Quadros, M.R., Souza, C.A., 1998. Immunoglobulin levels in workers exposed to hexachlorobenzene. Human Experimental Toxicology 17, 172-175.

Randolph, H.E., Barreiro, L.B., 2020. Herd Immunity: Understanding COVID-19. Immunity 52, 737-741.

Rooney, A.A., Matulka, R.A., Luebke, R.W., 2003. Developmental atrazine exposure suppresses immune function in male, but not female Sprague-Dawley rats. Toxicological Sciences 76, 366-375.

Rother, H., 2008. South African farm workers’ interpretation of risk assessment data expressed as pictograms on pesticide labels. Environmental Research 108, 419-427.

Rowe, A.M., Brundage, K.M., Barnett, J.B., 2007. In vitro atrazine-exposure inhibits human natural killer cell lytic granule release. Toxicology and Applied Pharmacology 221, 179-188.

Rowe, A.M., Brundage, K.M., Barnett, J.B., 2008. Developmental immunotoxicity of atrazine in rodents. Basic & Clinical Pharmacology & Toxicology 102, 139-145.

Saadi, H.S., Abdollahi, M., 2012. The importance of pesticides effects on human reproduction in farmers. Asian Network Scientific Information-Ansinet 308-Lasani Town, Sargodha Rd.

Salazar, K.D., Ustyugova, I.V., Brundage, K.M., Barnett, J.B., Schafer, R., 2008. A review of the immunotoxicity of the pesticide 3, 4-dichloropropionanalide. Journal of Toxicology and Environmental Health, Part B 11, 630-645.

Schaalan, M.F., Abdelraouf, S.M., Mohamed, W.A., Hassanein, F.S., 2012. Correlation between maternal milk and infant serum levels of chlorinated pesticides (CP) and the impact of elevated CP on bleeding tendency and immune status in some infants in Egypt. Journal of Immunotoxicology 9, 15-24.

Sunyer, J., Garcia-Esteban, R., Alvarez, M., Guxens, M., Goñi, F., Basterrechea, M., Vrijheid, M., Guerra, S., Antó, J.M., 2010. DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants. Epidemiology 21, 729-735.

Taylor, T.R., Tucker, T., Whalen, M.M., 2005. Persistent inhibition of human natural killer cell function by ziram and pentachlorophenol. Environmental Toxicology: An International Journal 20, 418-424.

Tomizawa, M., Casida, J.E., 2005. Neonicotinoid insecticide toxicology: mechanisms of selective action. Annual Review of Pharmacology and Toxicology 45, 247-268.

Ustyugova, I.V., Frost, L.L., VanDyke, K., Brundage, K.M., Schafer, R., Barnett, J.B., 2007. 3, 4-Dichloropropionaniline suppresses normal macrophage function. Toxicological Sciences 97, 364-374.

Vial, T., Nicolas, B., Descotes, J., 1996. Clinical immunotoxicity of pesticides. Journal of Toxicology and Environmental Health 48, 215-229.

Wilson, S., Dzon, L., Reed, A., Pruitt, M., Whalen, M.M., 2004. Effects of in vitro exposure to low levels of organotin and carbamate pesticides on human natural killer cell cytotoxic function. Environmental Toxicology: An International Journal 19, 554-563.


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