EVALUATION OF NEW, TRIAZOLOISOQUINOLINE AND PYRAZOLOPYRIDAZINE COMPOUNDS AGAINST THE DESERT LOCUST SCHISTOCERCA GREGARIA (ORTHOPTERA: ACRIDIIDAE)

Abstract

The present study deals with the bioactivities of 3-Acetyl[1,2,4]triazolo[3,4-a]isoquinoline was used to prepare a novel enaminone 5. Reactions of 5 with hydrazonoyl halides 6 gave triazoloisoquinolines 10 with a carbonylpyrazole as a side chain. Hydrazinolysis of 10 gave the pyrazolopyridazines 12. Bioactivity of these compounds was applied on 4^th nymphal instar of the desert locust Schistocerca gregaria. Results clearly showed that the compound 12b was the most effective against 4^th nymphal instars, while the compound 12a has the lowest effect. Meanwhile the chemical compounds, 10b and 10a were intermediate bioactive. In order of toxicity the lethal concentration was 0.31, 0.37, 0.46, and 0.57 of the chemical compounds 12b, 10b, 10a  and 12a respectively. On the other hand some deformation of the treated nymphs was observed by the effect of different chemical compounds due to molting inhibition for the next stages